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 Research in our group is directed toward the integration of “Nano”, “Bio”, and “Chem” at femtoliter, attoliter, and single molecule scales through nanofluidics. We continue to involve the study and development of novel nanofluidic methods and devices for single cell omics, single molecule chemistry, biomaterials, nanomedicine, energy, and process engineering. Click here for details.

Research Fields: Nanofluidics, Nano Chemical Systems, Microfluidics, NanoBio Interfaces, Biomaterials, Analytical Chemistry, Nanomedicine, Single Molecule Chemistry, Single-Cell Omics, Nano Energy
Featured Keywords: Nano-in-Nano Integration, Digital Nanochannels (DN), Single-Molecule Regulated Chemistry (SMRC)
Other Keywords: Nanochannels, Nanofluidic Channels, Nanofluidic Devices (Chips), Microchannels, Microfluidic Channels, Microfluidic Devices (Chips), Microchips, Lab on a Chip, MicroTAS, Single Molecule, Single Cell

Our Studies Featured on Journal Covers


News &. Topics

  • Join us: We welcome students and researchers from all over the world!
  • 2017/11/17 [Media Report] Our recent research progress is featured on Chinese International NEMS Network (CINN) and its mobile media. Click here for details.
  • 2017/11/09 [Media Report] Our recent research progress is featured on China Polymer Network (www.polymer.cn) and its mobile media. Click here for details.
  • 2017/09/14 [Invited Talk]Prof. Xu delivered an invited talk, entitled "NanoBioChem Integration at Femtoliter, Attoliter, and Single-Molecule Scales through Nanofluidics", at Southern University of Science and Technology (SUSTech).
  • 2017/09/13 All group members visited Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, and Southern University of Science and Technology (SUSTech), China.
  • 2017/09/12 [Keynote Talk]Prof. Xu delivered an keynote talk, entitled "Nanofluidics: A New Arena for Chemistry, Biology, and Materials Sciences", in 2017 SIAT-OPU Workshop on Nanofluidics and Biomedical Engineering.
  • 2017/09/12 2017 SIAT-OPU Workshop on Nanofluidics and Biomedical Engineering was held in Shenzhen, China. The workshop was co-chaired by Prof. Xu and hosted by Xu Lab, Shenzhen Institutes of Advanced Technology (SIAT), and University of Southern California. All group members attended the workshop.
  • 2017/07/26 [Invited Talk]Prof. Xu delivered an invited talk, entitled "Nanofluidics for Single-Cell Proteomics with Single-Molecule Sensitivity", in The 7th International Multidisciplinary Conference on Optofluidics 2017 (IMCO 2017) held in Singapore.
  • 2017/07/19 [Exhibition]Prof. Xu exhibited our technologies in The 107th Techno Lab Tour, a serial event of industry-academia collaboration event in OPU.
  • 2017/07/04 Our invited review paper entitled "Nanofluidics: a New Arena for Materials Science" is accepted for publication in Advanced Materials.
  • 2017/06/13 [Seminar]Prof. Osamu Ishibashi of Graduate School of Life and Environmental Sciences of OPU visited our lab and gave an invited talk.
  • 2017/05/19 [Invited Talk・Exhibition]Prof. Xu delivered an invited talk in The 106th Techno Lab Tour, a serial event of industry-academia collaboration event in OPU.
  • 2017/04/07 Ms. Haruka Ishibashi (B4) and Mr. Satoshi Nishioka (B4) joined our group. Welcome!
  • 2017/04/05 Ms. Kimiko Fukumoto joined our group as a Research Assistant. Welcome!
  • 2017/03/21 [Seminar]Prof. Junhong Chen of University of Wisconsin-Milwaukee visited our lab and gave an invited talk, entitled "Molecular Engineering of Real-Time Water Sensors Based on 2D Nanomaterials: from Concept to Product".
  • 2017/03/07 Mr. Takato Fujimoto (M1) won the Championship at Job Tryout.
  • 2017/03/01 Mr. Yamato Shiraishi (M1) of Hagiwara Lab at N2RC starts his laboratory rotation in our group. Welcome!
  • 2017/02/07 [Exhibition]Prof. Xu exhibited our technologies at JST Open Innovation Fair WEST2017.
  • 2017/02/06 [Seminar]Prof.Zhihong Li of Peking University visited our lab and gave an invited talk, entitled "Microelectrode arrays and sensors on flexible substrates".
  • 2016/12/28 [Invited Talk]Prof. Xu delivered an invited talk, entitled "Beyond the Bare Nanochannels: Exploring the Possibilities of Nanofluidics through Nano-in-Nano Integration", at University of Macau.
  • 2016/12/24 [Invited Talk]Prof. Xu delivered an invited talk, entitled "Nanofluidic Nanoarrays for Single Cell Omics with Single Molecule Sensitivity", in The 10th Shenzhen Symposium on Biomedical and Health Engineering held in Shenzhen, China.
  • 2016/11/29 [Keynote Talk]Prof. Xu delivered an keynote talk, entitled "Bridging World-to-Nanofluidics Interfaces through Nano-in-Nano Integration Technology", in IEEE MHS2016 held in Nagoya University.
  • 2016/11/04 Mr. Taichi Nakajima (M1) received The University President's Award for Students.
  • 2016/10/07 [Exhibition]Prof. Xu exhibited our technologies in The 4th Technology Seeds Forum of Kansai Branch, The Society of Chemical Engineers. 
  • 2016/09/14 [Invited Talk]Prof. Xu delivered an invited talk, entitled "Femtoliter-Scale Nanofluidic Analysis Enabled by Nano-in-Nano Integration Technology", in The 3rd Asian Symposium for Analytical Sciences (3rd ASAS) held in Hokkaido University.
  • 2016/09/03 Mr. Taichi Nakajima (M1) won the Championship at 2016 FreakOut Summer Job.
  • 2016/09/01 An invited commentary written by Prof. Xu appears on Journal of Society of Automotive Engineers of Japan. Click here for details. 
  • 2016/07/25 [Invited Talk]Prof. Xu delivered an invited talk, entitled "Active Regulation of Femtoliter-Scale Fluids in Nanochannel by Nano-in-Nano Technology", in The 6th International Multidisciplinary Conference on Optofluidics (Optofluidics 2016) held in Beijing.
  • 2016/07/22 [Invited Talk]Prof. Xu delivered an invited talk, entitled "NanoBio Interfaces Innovation Enables Nanofluidics: General Methodology, Critical Techniques, and NanoBio Applications", at Sichuan University.
  • 2016/06/19 [Media Report] Our recent research progress is featured on Advances in Engineering, which highlight papers of exceptional scientific importance to a broad scientific & engineering audience. Click here for details.
  • 2016/06/18 An invited commentary written by Prof. Xu appears on Chemistry, a Japanese popular science magazine published by Kagaku-Dojin Publishing Company,INC. Click here for details.
  • 2016/06/06 [Media Report] Univeristy official website (English version) reports our recent research progress. Click here for details.
  • 2016/04/08 Mr.Takehiro Tsujikawa(B4) and Mr. Hiroto Kawagishi (B4) joined our group. Welcome!
  • 2016/04/01 Prof. Xu was promoted as a tenured Associate Professor. Now, NanoBio Interfaces Labortory (NaBIL) in NanoSquare freshly started as Yan Xu's Nanofluidics Lab in Department of Chemical Engineering, Graduate School of Engineering.
  • 2016/03/09 An invited commentary written by Prof. Xu, entitled "On-Chip Cell Preservation by Using a Phospholipid Polymer Hydrogel", is accepted for publication in Journal of the Japan Society of colour Material.
  • 2016/03/03 [Media Report] Our recent research progress is reported by The Asahi Shimbun. Click here for details.
  • 2016/03/01 Mr. Toshiyuki Kawabata joined our group as a Research Assistant. Welcome!
  • 2016/02/24 Ms. Misato Shinomiya (M2) received 'Applied Chemistry (Ouka) Award' of FY2015.
  • 2016/01/25 [Media Report] Our recent research progress is reported by Mynavi Student. Click here for details.
  • 2016/01/22 [Media Report] Our recent research progress is reported by OPTRONICS ONLINE. Click here for details.
  • 2016/01/21 [Media Report] Our recent research progress is reported by Mynavi News. Click here for details. Livedoor News, Excite News, goo News, @nifty news, BIGLOBE News, etc. reproduce the report.
  • 2016/01/21 [Press Release] Univeristy official website releases our recent research progress. Click here for details. research-er.jp, etc. reproduce the release.
  • 2016/01/20 Research paper (Soft Matter-Regulated Active Nanovalves Locally Self-Assembled in Femtoliter Nanofluidic Channels)is published online in Advanced Materials.
  • 2015/12/08 Research results concerning An Integrated Glass Nanofluidic Device Enabling in situ Electrokinetic Probing of Water Confined in a Single Nanochannel under Pressure-Driven Flow Conditions are featured on the inside front cover of Small (2015, Vol. 11, Issue 46)
  • 2015/12/02 In "coming soon" of today's published Small (Vol. 11, Issue 45), our paper ( An Integrated Glass Nanofluidic Device Enabling in situ Electrokinetic Probing of Water Confined in a Single Nanochannel under Pressure-Driven Flow Conditions) is introduced as a VIP (very important paper) of the upcoming issue (Vol. 11, Issue 46).
  • 2015/11/30 Research results concerning "Soft Matter-Regulated Active Nanovalves Locally Self-Assembled in Femtoliter Nanofluidic Channels" are accepted for publication in Advanced Materials.
  • 2015/11/06 [Invited Talk]Prof. Xu delivered an invited talk, entitled "Site-specific working inside nanofluidic channels: general methodology, critical techniques, and nanobio applications", in The 2nd FZU-OPU Joint International Symposium held in Fuzhou University, China.
  • 2015/11/05 [Invited Talk]Prof. Xu delivered an invited talk, entitled "Nanobio interfaces innovation enabling nanofluidics: general methodology, critical techniques, and nanobio applications", at Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences.
  • 2015/11/01 Ms. Qian Wu (M2) and Mr. Taichi Nakajima (B4) received The University President's Award for Students.
  • 2015/10/20 Mr. Yuji Shimatani (M1) received 'The MicroTAS2015 Travel Grant' from MicroTAS2012 Memorial Foundation of CHEMINAS.
  • 2015/10/05 Research results concerning Spontaneous Packaging and Hypothermic Storage of Mammalian Cells with a Cell-Membrane-Mimetic Polymer Hydrogel in a Microchip are accepted for publication in ACS Applied Materials & Interfaces.
  • 2015/10/01 Ms. Jiayi Sun (B4) of Department of Applied Chemistry, School of Engineering, joined our group as a joint research student. Welcome!
  • 2015/09/17 Research results concerning An Integrated Glass Nanofluidic Device Enabling in situ Electrokinetic Probing of Water Confined in a Single Nanochannel under Pressure-Driven Flow Conditions are accepted for publication in Small. The "manuscript has been judged to be very important and very urgent" by Small.
  • 2015/09/16 Research results concerning Regeneration of Glass Nanofluidic Chips through a Multiple‐Step Sequential Thermochemical Decomposition Process at High Temperatures are featured on the back cover of Lab on a Chip (2015, Vol. 15, Issue 19).
  • 2015/08/12 Prof. Xu received The University President's Award for his research achievement in 2014.
  • 2015/08/04 Research results concerning Regeneration of Glass Nanofluidic Chips through a Multiple‐Step Sequential Thermochemical Decomposition Process at High Temperatures are accepted for publication in Lab on a Chip.
  • 2015/07/29 [Invited Talk]Prof. Xu delivered an invited talk, entitled "Site-specific working inside nanofluidic channels: general methodology, critical techniques, and nanobio applications", in The 5th International Conference on Optofluidics (Optofluidics 2016) held in Taipei.
  • 2015/06/11 [Seminar]Prof. Itsuo Hanasaki of Osaka University visited our lab and gave an invited talk.
  • 2015/05/23 Research results concerning Flexible and In-Situ Fabrication of Nanochannels with High Aspect Ratios and Nanopillar Arrays in Fused Silica Substrates Utilizing Focused Ion Beam are accepted for publication in RSC Advances.
  • 2015/04/21 Research results concerning Site-Specific Nanopatterning of Functional Metallic and Molecular Arbitrary Features in Nanofluidic Channels are featured on the back cover of Lab on a Chip (2015, Vol. 15, Issue 9).
  • 2015/04/18 [Invited Talk]Prof. Xu gave a science talk entitled 'microfluidic chips for chemistry' for local middle school students.
  • 2015/03/09 Research results concerning Site-Specific Nanopatterning of Functional Metallic and Molecular Arbitrary Features in Nanofluidic Channels are published in Lab on a Chip.
  • 2015/03/07 [Invited Talk]Prof. Xu gave a science seminar for general public (Nanosquare Cafe), entitled 'Forefront of micro-/nanofluidic technology', at I-site Namba of OPU.
  • 2015/02/27 Mr.Taichi Nakajima(B4) and Mr. Takato Fujimoto (B4) of Department of Physical Science, School of Science, College of Life, Environment, and Advanced Sciences, joined our group. Welcome!
  • 2015/01/05 [Invited Talk]Prof. Xu delivered an invited talk, entitled "Functionalization of Nanofluidic Channels and its Application to NanoBio Sciences", in Summit of Biomedical and Health Engineering 2015 held in Shenzhen, China.
  • 2014/12/01 [Seminar]Prof. Yo Tanaka of RIKEN visited our lab and gave an invited talk.
  • 2014/10/06 [Seminar]Prof. Tianzhun Wu of Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences visited our lab and gave an invited talk, entitled "Microfabrication-aided wetting and mass transfer for droplet microfluidics"
  • 2014/09/12 [Exhibition]Prof. Xu exhibited our technologies at Innovation Japan 2014.
  • 2014/09/05 Ms. Misato Shinomiya received Best Poster Award at 2014 N2RC Fall Joint Seminar.
  • 2014/08/11 Prof. Xu received The University President's Award for his research achievement in 2013.
  • 2014/06/03 Ms. Fumiyo Nakata joined our group as a secretary. Welcome!
  • 2014/05/22 Prof. Xu received Young Innovator Award on Chemistry and Micro-Nano Systems (CHEMINAS Young Innovator Award).
  • 2014/04/04 Ms. Qian Wu (M1) of Department of Chemistry, Graduate School of Science and Mr. Kogi Yamaguchi (B4) of Department of Applied Chemistry, School of Engineering, joined our group. Welcome!
  • 2014/03/24 Mr. Nobuhiro Matsumoto (M2) received 'The Murata Award' of Department of Physics and Electronics, Graduate School of Engineering.
  • 2014/03/17 Prof. Xu is appointed as a Visiting Associate Professor of Shenzhen Institutes of Advanced Technology (SAIT), Chinese Academy of Sciences.
  • 2014/03/10 Prof. Xu's co-authored paper, entitled 'Determination of Cattle Foot-and-Mouth Disease Virus by Micro-ELISA Method', is published in Analytical Sciences as a Hot Article.
  • 2014/03/04 Prof. Xu's co-authored paper, entitled 'Aptamer and Its Potential Applications for Food Safety' is published in Critical Reviews in Food Science and Nutrition.
  • 2013/10/05 Mr. Nobuhiro Matsumoto (M2) was selected to receive a student travel grant to attend The 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013) from the Chemical and Biological Microsystems Society (CBMS) in Freiburg, Germany. Congratulations!!
  • 2013/09/25 Mr. Yuji Shimatani (B3) of Department of Chemistry, School of Science, joined our group. Welcome!
  • 2013/05/19 Prof. Xu received the Springer Silver Scholar Award at ISMM2013.
  • 2013/04/08 Ms.Misato Shinomiya (B4) of Department of Applied Chemistry, School of Engineering, joined our group. Welcome!
  • 2013/03/06 Mr. Atsushi Matsuoka (B4) and Ms. Baihui Xu (B4) of Department of Materials Science, School of Engineering, joined our group. Welcome!
  • 2013/01/24 The Japanese title of the lecture (Nanoscience and Nanotechnology XI) given by Prof. Xu is changed. Please see new syllubus.
  • 2013/01/09 Research results concerning Bonding of glass nanofluidic chips at room temperature by a one-step surface activation using an O2/CF4 plasma treatment are published in Lab on a Chip.
  • 2013/01/01 A happy new year!
  • 2012/12/16 The book 'Silane: Chemistry, Applications and Performance' is published. Prof. Xu authored the Chapter 1, entitled 'Modification of Glass Substrates and Microfluidic Devices by Silanization of Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine (MPC) Polymers for Preparing Biocompatible Interfaces'.
  • 2012/12/07 Prof. Xu's co-authored paper, entitled 'Femtoliter droplet handling in nanofluidic channels: a Laplace nanovalve', is published in Analytical Chemistry.
  • 2012/08/03 Prof. Xu's scientific article, entitled 'Development of cell chips based on biocompatible polymers', is published in Journal of Japanese Society for Biomaterials.
  • 2012/07/13 Prof. Xu's co-authored paper, entitled 'Micropatterning of biomolecules on a glass substrate in fused silica microchannels by using photolabile linker-based surface activation', is published in Microchimica Acta.
  • 2012/03/23 Mr. Matsumoto attended his graduation ceremony. He graduated from Department of Physics and Electronics. Congratulations!
  • 2012/02/21 Mr. Matsumoto presented his graduation thesis research in the graduation defence examination of Department of Physics and Electronics.
  • 2012/01/01 A happy new year!
  • 2011/12/03 Research results concerning Low-temperature direct bonding of glass nanofluidic chips using a two-step plasma surface activation process are published in Analytical and Bioanalytical Chemistry (Online First).
  • 2011/10/10 Prof. Xu's co-authored paper, entitled "Development of microfluidic platform for single-cell secretion analysis using a direct photoactive cell-attaching method", is published in Analytical Sciences and highlighted on the journal cover as a Hot Article. 
  • 2011/09/21 Prof. Xu's co-authored Book Chapter, entitled "Cytocompatible hydrogel composed of phospholipid polymers for regulation of cell functionalities" in "Advances in Polymer Sciences, 'Polymers in Nanomedicine'", is published by Springer Berlin/Heidelberg.
  • 2011/09/02 Mr. Matsumoto passed the examination of admission to the Master course. Congratulations!
  • 2011/08/16 Prof. Xu's trends article, entitled "Microchip-based cellular biochemical systems for practical applications and fundamental research: from microfluidics to nanofluidics", has been fisrt published online in Analytical and Bioanalytical Chemistry for its 10th Anniversary Issue.
  • 2011/07/08 Research results concerning A microfluidic method to screen swine type O foot-and-mouth disease virus (FMDV) are published in Lab on a Chip.
  • 2011/07/07 Yan Xu's research group has launched a website homepage.
  • 2011/07/06 Ms. Noriko Tano joined our group as a secretary. Welcome!
  • 2011/04/08 Mr. Nobuhiro Matsumoto (B4) of Department of Physics and Electronics, School of Engineering, joined our group. Welcome!
  • 2011/04/01 Prof. Xu moved from the University of Tokyo and has started up his own research group, NanoBio Interfaces Laboratory (NaBIL).

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