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Our research was featured on the inside front cover of Small

Using a pair of nanoelectrodes embedded within a tiny nanochannel space on a novel nanofluidic chip, Y. Xu and B. Xu demonstrate the in-situ probing of anomalous electrokinetic behaviors of water confined in nanospaces. On page 6165, these measurements provide the first in-situ experimental evidence for the existence of the unusual nature of water confined in nanospaces. The understanding gained is very helpful for elucidating physical, chemical, biological, and life phenomena occurring in small spaces. Small, 2015, doi: 10.1002/smll.201570275

In-situ measurement of streaming currents in a single nanochannel with femtoliter-scale volumes is achieved using an elaborately designed and fabricated glass nanofluidic chip with probe electrodes embedded within the nanochannel. The device and the method suggest a useful nanoscale tool enabling in situ understanding of the unique liquid properties observed in nanofluidic channels. Small, 2015, (doi:10.1002/smll.201502125)


TOC Graphic:ACS Applied Materials & Interfaces (doi:10.1021/acsami.5b06796)

We report spontaneous packaging and hypothermic storage of mammalian cells under refrigerated (4 °C) and ambient conditions (25 °C) using a cell-membrane-mimetic methacryloyloxyethyl phosphorylcholine (MPC) polymer hydrogel incorporated within a glass microchip.The approach would be a promising miniature and portable solution for flexible supply and delivery of small amounts of cells from bench to bedside. ACS Applied Materials & Interfaces, 2015, (doi:10.1021/acsami.5b06796)



Our research was featured on the inside back cover of Lab on a Chip

A simple method for the total regeneration of glass nanofluidic chips was described. The method provides a technical solution to significantly improve the reusability of glass nanofluidic chips and will be useful for the promotion and acceleration of research and applications on nanofluidics. Lab on a Chip, 2015, 15, 3856-3861 (doi:10.1039/C5LC00604J)


TOC Graphic:RSC Advances (doi:10.1039/C5RA06306J)

Nanochannels fabricated in fused silica substrates are ideal tools for single (bio)molecular studies in biology and are promising in the development of innovative applications in chemistry. To obtain a higher throughput and a higher level of integration and functionalization, nanochannels with high aspect ratios and nano-in-nano structures are very much desired, but their fabrication is a challenge. Herein, we report a method for fabricating nanochannels with such challenging critical dimensions and structures in fused silica substrates by using a focused ion beam. RSC Advances, 2015, 5, 50638-50643. (doi: 10.1039/C5RA06306J)


Our research was featured on the inside back cover of Lab on a Chip

A general method for site-specific nanopatterning of functional metallic and molecular arbitrary features in glass nanofluidic channels was established. The method opens the way for precise functionalization of nanofluidic channels, which has been greatly challenging in the field of nanofluidics. Lab on a Chip, 2015, 15, 1989-1993. (doi: 10.1039/C5LC00190K)
 


TOC Graphic: Analytical Sciences (doi:10.2116/analsci.30.359)

 
 A microchip-based enzyme-linked immunosorbent assay (micro-ELISA) method capable of detecting the cattle foot-and-mouth disease virus(FMDV) was developed.


TOC Graphic: Lab on a Chip (doi:10.1039/C3LC41345D)

 
 The strong, nanostructure-friendly, and high pressure-resistant bonding of glass nanofluidic chips at room temperature by an O2/CF4 gas mixture plasma treatment is achieved


TOC Graphic: Analytical Chemistry(doi:10.1021/ac3028905)

 
 The basic principle of a Laplace nanovalve was verified, and a 1.7 fL droplet (water in air) was successfully generated and handled for the first time.


TOC Graphic: Microchimica Acta (doi:10.1007/s00604-012-0856-8)

 
 This technique was based on combining 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer, which is known to non-biofouling compound, photocleavable linker (PL) that was modified to localize cells and to connect between MPC polymer and amino-terminated silanized surface. Using ultraviolet (UV) light illumination, MPC polymer can be selectively eliminated by photochemical reaction in order which resulted in micropatterning of multiple biomolecules


TOC Graphic: Analytical and Bioanalytical Chemistry(doi:10.1007/s00216-011-5574-2)

 
 Direct bonding of fused silica glass nanofluidic chips at low temperature, around 200 °C in ambient air, through a two-step plasma surface activation process which consists of an O2 RIE plasma treatment followed by a nitrogen MW radical activation


Our research was highlighted on the cover of Analytical Sciences.

 

We modified a newly designed microchip for single-cell analysis and regulated the cell-adhesive area inside a cell-chamber of the microfluidic system by using surface-modification techniques involving a silanization compound, a photo-labile linker and the 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer covalently bonded on the surface of a microchannel. Analytical Sciences, 2011, 27, 973-978. (doi:10.2116/analsci.27.973)

 



TOC Graphic: Analytical and Bioanalytical Chemistry,
(doi: 10.1007/s00216-011-5296-5)

 

 By combination of cell technology and microchip technology, innovative cellular biochemical tools can be created from the microscale to the nanoscale, for both practical applications and fundamental research. The image demonstrates a concept of analysis of a single cell at the single molecule level on a microchip with integration of extended-nano (101-103 nm) space.



TOC Graphic: Lab on a Chip, 2011, 11, 2153-2155. (DOI: 10.1039/C0LC00678E)

 

 In order to tackle both regional and global foot-and-mouth disease virus (FMDV) epdimics, we hereby develop a rapid microfluidic thermal lens microscopic method to screen swine type O FMDV with good efficiency. The scheme has great merits in terms of field portability, sample volume, assay time, analytical sensitivity, and test reproducibility.



Our research was highlighted on the cover of Advanced Materials.

 

 We report on a phospholipid polymer hydrogel that exhibits a remarkable ability to preserve cells on microfluidic chips without perfusion culture under cell-based assay conditions, with characteristics including maintenance of high cell viability, restraint of cell proliferation, and minimization of cellular function loss over a period of days and weeks. This material could establish a revolutionary flexibility for cellbased applications. Advanced Materials, 2010, 22, 3017-3021. (DOI: 10.1002/adma.201000006)

 


TOC Graphic: Lab on a Chip, 2010, 10, 1937-1945. (DOI: 10.1039/C002239J)

 

 A simple and direct approach for cell patterning inside the microchannel using photochemical reaction.


TOC Graphic: Biomacromolecules, 2009, 10, 267-274. (DOI: 10.1021/bm801279y) 

 

 High capability of a charged interface to suppress adsorption of both anionic and cationic proteins was reported.


Our research was highlighted on the cover of Lab on a Chip

 

 Charged phospholipid interfaces in microchannels allow the simultaneous control of multiple electroosmotic flows and simultaneously suppress non-specific bioadsorptions. Lab on a Chip, 2007, 7,199-206. (DOI: 10.1039/B616851P)


 

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