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研究業績(Publications)

Scientific Articles

2017
2016
2015
2014
  • Determination of cattle foot-and-mouth disease virus by micro-ELISA method
    Yiyang Dong, Yan Xu, Zaixin Liu, Yuanfang Fu, Toshinori Ohashi, Kazuma Mawatari, Takehiko Kitamori
    Analytical Sciences
    , 2014, 30, 359-363. (doi:10.2116/analsci.30.359) [PDF]
    (
    Selected as a "Hot Article")
  • Aptamer and its potential applications for food safety
    Yiyang Dong, Yan Xu, Wei Yong, Xiaogang Chu, Daning Wang
    Critical Reviews in Food Science and Nutrition
    , 2014, 54, 1548-1561. (doi:10.1080/10408398.2011.642905) [PDF]
  • マイクロ・ナノ空間の機能化表面・界面の構築と制御
    許岩
    化学とマイクロ・ナノシステム
    , 2014,13, 2, 20.
  • Design, synthesis and characterization of a thiolated temperature-responsive polymer for smart nanofluidic control
    Misato Shinomiya, Atsushi Harada, Yan Xu
    Proceedings of Micro Total Analysis Systems, 2014, 1841-1843.[PDF]
2013 2012 2011 2010 2009 2008 2007 2006
  • Constructing biomembrane-mimic interface for cell separation in microfluidic chip
    Yan Xu, Madoka Takai, Kazuhiko Ishihara
    Transactions of Materials Research Society of Japan, 2006, 31, 645-648.
  • Protein antiadsorption modification by negatively charged phospholipid polymer for microsystem needing electroosmotic flow
    Yan Xu, Madoka Takai, Tomohiro Konno, Kazuhiko Ishihara
    Proceedings of Micro Total Analysis Systems, 2006, 1, 215-217.
Before 2006


Patents

  • Ma Xiaojun, Xu Yan, Wang Wei. Calcium alginate gel microsphere soft tissue reinforced material and its preparation method and application. China Patent, Patent Number(s): CN1628862-A, CN1306968-C.
  • Ma Xiaojun, Xu Yan, Wang Wei.. Chitosan-calcium alginate gel microsphere soft tissue reinforced material and its preparation method and application. China Patent, Patent Number(s): CN1628861-A, CN1318100-C


Conference Oral Presentations

  • Xu Yan, Takai Madoka, Kitamori Takehiko. Bioinspired micro/nano interfaces and devices based on 2-methacryloyloxyethyl phosphorylcholine polymers, "15th International Conference on Thin Films, 2011 (ICTF-15)". Kyoto, Japan, Nov., 2011.
  • Xu Yan. Creation of micro/nano interfaces and integrated devices at the molecular and cellular levels, “Aptamer and Microfluidic Seminar for Food Ssafety and Related Science”. Beijing, China, Oct., 2011. (Invited)
  • Umeda Jun, Wang Chenxi, Xu Yan, Mawatari Kazuma, Kitamori Takehiko, Suga Tadatomo. Low temperature bonding of glasses by means of surface activation using water, "25th Spring Conference of Japan Institute of Electronics Packaging". Yokohama, Japan, Mar., 2011.
  • Jang Kihoon, Kogo Atsushi, Mawatari, K.; Xu Yan, Kitamori Takehiko. Heat pipe with extended nanopillar inside the micro-nano combined chip. "The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)". Hawaii, USA, Dec., 2010.
  • Xu Yan, Kitamori Takehiko. Partial Surface Modification Methods for Extended-Nano Space Using Nanostructure Fabrication. "2nd Iwan Wark Research Institute Joint Seminar". Adelaide, Australia, Dec., 2009.
  • Xu Yan, Sato Kae, Konno Tomohiro, Ishihara Kazuhiko, Kitamori Takehiko. Cell-based assays on a chip with a cell bank. "23rd International Symposium on Microscale Bioseparations(MSB)". Boston, USA, Feb. 2009.
  • Xu Yan, Takai Madoka, Ishihara Kazuhiko. Nonbiofouling anionic phospholipid polymer modification for electrokinetic microfluidic device. "The Society For Biomaterials (SFB) 2007 Annual Meeting and Exposition". Chicago, USA. Apr. 2007.
  • Xu Yan, Takai Madoka, Ishihara Kazuhiko. Control of microflow on polymer biointerface in electrokinetic microfluidic device. "The Japan Society of Applied Physics (JSAP) 2007 Spring Annual Meeting". Sagamihara, Japan. Mar. 2007.
  • Xu Yan, Takai Madoka, Konno Tomohiro, Ishihara Kazuhiko. Cell-membrane-like interface constructed for microfluidic flow control. "2nd UT-SNU-TU Student Workshop". Beijing, China. Oct. 2006.
  • Takai Madoka, Sibarani James, Xu Yan, Ishihara Kazuhiko. Protein adsorption resistance on biochip surface by phospholipid polymers. "20th European Conference on Biomaterials (ESB2006)". Nantes, France. Sep. 2006.
  • Xu Yan, Takai Madoka, Konno Tomohiro, Ishihara Kazuhiko. Antiprotein adsorption interface on biochip prepared by a negatively charged phospholipid polymer. "7th Asian Symposium on Biomedical Materials (ASBM-7)". Jeju, Korea. Aug., 2006.
  • Ishihara Kazuhiko,Takai Madoka, Xu Yan. Phospholipid polymer biointerfaces on nanobiodevices. "International Symposium on Polymer Chemistry (PC'2006)". Dalian, China. Jun., 2006. (Invited)
  • Xu Yan, Takai Madoka, Ishihara Kazuhiko. Microfluidic devices with "smart" surface for cell separation. "The Japanese Society for Biomaterials 27th Annual Meeting". Kyoto, Japan. Oct. 2005.


Conference Poster Presentations

2012
  • Xu Y., Wang C, Jang K, Li L, Matsumoto N., Dong Y., Mawatari K., Suga T., Kitamori T. A room-temperature bonding of glass nanofluidic chips utilizing a surface activation with a fluorine-containing plasma treatment. "16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2012)". Okinawa, Japan, Oct. 2012.
  • Jang K., Wang C., Xu Y., Kitamori T. Development of fluorine induced plasma activating room-temperature bonding stratage for high-pressure micro-nano fluidic devices. "16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2012)". Okinawa, Japan, Oct. 2012.
  • Mawatari K., Kubota S., Xu Y., Kitamori T. Nano Laplace valve for femtolitter liquid generation and handling realized by nanopillar-in-nanochannel fabrication and surface modification. "16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2012)". Okinawa, Japan, Oct. 2012.
  • Xu Yan, Wang Chenxi, Li Lixiao, Matsumoto Nobuhiro, Jang Kihoon, Dong Yiyang, Mawatari Kazuma, Suga Tadatomo, Kitamori Takehiko. A novel bonding method of glass nanofluidic chips at room temperature. “4th International Symposium on Microchemistry and Microsystems (ISMM 2012)”. Hsinchu, Jun., 2012.
  • Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. Attoliter scale liquid handling using Laplace valve in Extended Nanospace. “4th International Symposium on Microchemistry and Microsystems (ISMM 2012)”. Hsinchu, Jun., 2012.
  • Wang Chenxi, Xu Yan, Jang Kihoon, Shirai Kentaro, Mawatari Kazuma, Suga Tadatomo, Kitamori Takehiko. Precise Alignment Technique for Creating Micro/Nanofluidic Devices. “4th International Symposium on Microchemistry and Microsystems (ISMM 2012)”. Hsinchu, Jun., 2012.
  • Xu Yan, Wang Chenxi, Li Lixiao, Matsumoto Nobuhiro, Jang Kihoon, Dong Yiyang, Mawatari Kazuma, Suga Tadatomo, Kitamori Takehiko. A super high pressure resistant bonding of glass nanochannels at room temperature using an O2/CF4 gas mixture plasma treatment for nanochromatography sample handling. "27th International Symposium on MicroScale BioSeparations and Analyses (MSB2012)". Geneva, Switzerland, Feb., 2012.
  • Jang Kihoon, Xu Yan, Mawatari Kazuma, Kitamori Takehiko. Simplified room-temperature bonding of fused silica glass micro-nanofluidic device by using fluorine induced plasma treatment with Teflon pieces. "27th International Symposium on MicroScale BioSeparations and Analyses (MSB2012)". Geneva, Switzerland, Feb., 2012.
2011
  • 久保田翔吾、馬渡和真、許岩、北森武彦.  拡張ナノ空間におけるアトリットル操作のためのラプラスバルブの開発. 「第24回化学とマイクロ・ナノシステム研究会」. 大阪、Nov., 2011.
  • Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. Laplace pressure valve utilizing nano-in-nano structure toward attoliter scale liquid handling. "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2011)". Seattle, USA, Oct. 2011.
  • Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. Development of aL scale liquid handling method in extended nanospace. “JAIMA Discussion on Analytical Science and Technology 2011, International Session”. Chiba, Japan, Sept. 2011.
  • Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. Development of Laplace Pressure Valve for Chromatography System in Extended-nano Space. "The 36th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2011)". Budapest, Hungary, Jun, 2011.
  • Xu Yan, Wang Chenxi, Li Lixiao, Dong Yiyang, Jang Kihoon, Suga Tadatomo, Mawatari Kazuma, Kitamori Takehiko. Low-temperature glass chip bonding. "The International Symposium on Microchemistry and Microsystems 2011 (ISMM 2011)". Seoul, Korea, Jun., 2011.
  • Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. A Laplace valve in extended-nano channel for attoliter-level liquid injection. "The International Symposium on Microchemistry and Microsystems 2011 (ISMM 2011)". Seoul, Korea, Jun., 2011.
  • Jang Kihoon, Ngo Thi Hong Trang, Tanaka, Yo, Xu Yan, Kitamori Takehiko. Development of single cell analysis device using single cell-array and culture techniques in a microfluidic system. "The International Symposium on Microchemistry and Microsystems 2011 (ISMM 2011)". Seoul, Korea, Jun., 2011.
  • Xu Yan, Wang Chenxi, Dong Yiyang, Jang Kihoon, Suga Tadatomo, Mawatari Kazuma, Kitamori Takehiko. Bonding of glass nanofluidic chips at low temperature. "IUPAC International Congress on Analytical Sciences 2011 (ICAS 2011)". Kyoto, Japan, May, 2011.
  • Dong Yiyang, Xu Yan, Liu Zaixin, Fu Yuanfang, Ohashi Toshinori, Mawatari Kazuma, Kitamori Takehiko. Screening swine type O foot-and-mouth disease virus with micro-beads based microfluidic thermal lens microscopy. "IUPAC International Congress on Analytical Sciences 2011 (ICAS 2011)". Kyoto, Japan, May, 2011.
  • Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. A Laplace pressure valve to control nanofluidics for chromatography systems in extended-nano space. "IUPAC International Congress on Analytical Sciences 2011 (ICAS 2011)". Kyoto, Japan, May, 2011.
  • Jang Kihoon, Iseki Keizo, Kogo Atsushi, Xu Yan, Mawatari Kazuma, Sugii Yasuhiko, Kitamori Takehiko. A flat heat pipe system contained capillary condensation and vapor-liquid coexisting process based on extended nanopillar. "IUPAC International Congress on Analytical Sciences 2011 (ICAS 2011)". Kyoto, Japan, May, 2011.
  • Wang Chenxi, Xu Yan, Umeda Jun,Dong Yiyang, Mawatari Kazuma, Kitamori Takehiko, Suga Tadatomo. A novel biocompatible direct bonding for glass microdevices. "International Conference on Electronics Packaging 2011 (ICEP 2011)". Nara, Japan, Apr. 2011.
2010
  • Xu Yan, Jang Kihoon, Mawatari Kazuma, Konno Tomohiro, Ishihara Kazuhiko, Kitamori Takehiko. A microfluidic hydrogel for more flexible cell-based applications. "The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)". Hawaii, USA, Dec., 2010.
  • Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. Development of Laplace valves capable of attoliter level injection for chromatography systems in extended-nano space. "10th Asian-Pacific International Symposium on Microscale Separations and Analysis (APCE 2010)". Hongkong, China, Dec., 2010.
  • Xu Yan, Jang Kihoon, Mawatari Kazuma, Konno Tomohiro, Ishihara Kazuhiko, Kitamori Takehiko. Cell-based toxin screening integrated with a cell-sustainable hydrogel on chip for onsite and portable applications. "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2010)". Groningen, The Netherlands, Oct., 2010.
  • Jang Kihoon, Xu Yan, Tanaka Yo, Kitamori Takehiko. Multi-patterning of biological samples on glass substrate and inside the fused microchannel by using photochemical reaction. "17th International Symposium on Capillary Electroseparation Techniques (ITP 2010 USA)". Baltimore, USA, Aug, 2010.
  • Xu Yan, Ishihara Kazuhiko, Kitamori Takehiko. A microfluidic cell-based biosensor with integration of a phospholipid polymer hydrogel for onsite and portable applications. "Gordon Research Conferences-Bioanalytical Sensors". New London, USA, Jun., 2010.
  • Jang Kihoon, Xu Yan, Tanaka Yo, Mawatari Kazuma, Kitamori Takehiko. Direct approach to modify individual cells in microfluidic device for single cell analysis. "21th Symposium on Chemistry and Micro-Nano Systems". Tokyo, Japan. Jun., 2010.
  • Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. Development of Laplace valves in extended-nano space using nano fabrication. "21th Symposium on Chemistry and Micro-Nano Systems". Tokyo, Japan. Jun., 2010.
  • Xu Yan, Jang Kihoon, Konno Tomohiro, Ishihara Kazuhiko, Mawatari Kazuma, Kitamori Takehiko. Comparative investigation on long-term cellular functions of cells in a microfluidic hydrogel capable of cell preservation. "International Symposium on Microchemistry and Microsystems (ISMM) 2010". Hongkong, China, May, 2010.
  • Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. Development of Laplace valve in extended-nano space using well-defined patterning by nanostructure. "International Symposium on Microchemistry and Microsystems (ISMM) 2010". Hongkong, China, May, 2010.
  • Jang Kihoon, Xu Yan, Tanaka Yo, Kitamori Takehiko. A method for single cell patterning by using photochemical reaction in fused micrcoahnnel. "International Symposium on Microchemistry and Microsystems (ISMM) 2010". Hongkong, China, May, 2010.
  • Xu Yan, Jang Kihoon, Konno Tomohiro, Ishihara Kazuhiko, Mawatari Kazuma, Kitamori Takehiko. A microfluidic hydrogel for long-term cell preservation under cell-based assay conditions. "25th International Symposium on Microscale Bioseparations (MSB)". Prague, Czech, Mar., 2010.
  • Jang Kihoon, Xu Yan, Tanaka Yo, Kitamori Takehiko. Single cell patterning in semi-closed microchannel using photoactivation. "25th International Symposium on Microscale Bioseparations (MSB)". Prague, Czech, Mar., 2010.
2009
  • Xu Yan, Sato Kae, Konno Tomohiro, Ishihara Kazuhiko, Kitamori Takehiko. An on-chip living cell bank. "13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2009)". Jeju, Korea. Nov., 2009.
  • Xu Yan, Mawatari Kazuma, Konno Tomohiro, Ishihara Kazuhiko, Kitamori Takehiko. Cell bank on chip working at room temperature. "24th International Symposium on Microscale Bioseparations (MSB)". Dalian, China, Oct., 2009.
  • Xu Yan, Sato Kae, Mawatari Kazuma, Konno Tomohiro, Ishihara Kazuhiko, Kitamori Takehiko. Long-term cell preservation in chip at room temperature. "19th Symposium on Chemistry and Micro-Nano Systems". Hiroshima, Japan. May, 2009.
2008
  • Xu Yan, Sato Kae, Konno Tomohiro, Ishihara Kazuhiko, Kitamori Takehiko. Cell-based assays supported by a cell bank on chip. "International Symposium on Microchemistry and Microsystems (ISMM) 2008". Kyoto, Japan. Dec. 2008.
  • Xu Yan, Konno Tomohiro, Sato Kae, Ishihara Kazuhiko, Kitamori Takehiko. Long-term storage of living cells on chip for cell-based assays. "12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2008)". San Diego, USA. Oct., 2008.
  • Xu Yan, Takai Madoka, Konno Tomohiro, Ishihara Kazuhiko. Suppressing bioadsorption on electrokinetic microdevice by a charged phospholipid polymer biointerface. "8th World Biomaterials Congress (WBC2008)". Amsterdam, The Netherlands. May, 2008.
  • Xu Yan, Sato Kae, Konno Tomohiro, Ishihara Kazuhiko, Kitamori Takehiko. Long-term encapsulation of living cells on chip by using a phospholipid polymer hydrogel. "17th Symposium on Chemistry and Micro-Nano Systems". Fukuoka, Japan. May, 2008.
2007
  • Xu Yan, Konno Tomohiro, Takai Madoka, Ishihara Kazuhiko. Charged phospholipid polymer surfaces with high cell adhesion resistance for cell chip. "11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2007)". Paris, France. Oct., 2007.
  • Xu Yan, Takai Madoka, Ishihara Kazuhiko. Phospholipid polymer surface for control of both protein adsorption and liquid flow in microfluidic device. "The Society of Polymer Science Japan (SPSJ) 56th Annual Meeting". Kyoto, Japan. May, 2007.
2006
  • Xu Yan, Takai Madoka, Konno Tomohiro, Ishihara Kazuhiko. Protein antiadsorption modification by negatively charged phospholipid polymer for microsystem needing electroosmotic flow. "10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2006)". Tokyo, Japan. Nov., 2006.
  • Xu Yan, Takai Madoka, Konno Tomohiro, Ishihara Kazuhiko. Biomembrane mimetic anti-bioadsorption interface constructed for microfluidic devices. "The Society of Polymer Science Japan (SPSJ) 55th Annual Meeting". Nagoya, Japan. May, 2006.
2005
  • Xu Yan, Takai Madoka, Ishihara Kazuhiko. Constructing biomembrane-mimic interface in microfluidic chip for cell separation. "16th Materials Research Society (MRS)-Japan Academic Symposium". Tokyo, Japan. Dec., 2005.
  • Xu Yan, Konno Tomohiro, Ishihara Kazuhiko, Takai Madoka. Microfluidic interface constructed by biomimic membrane for cell separation chip. "Asian Conference on Recent Trends in Colloid and Surface Science (ACCASS)". Nagoya, Japan. Dec., 2005.

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