Generation of nanometer-scale geometrical gas-liquid interfaces in hydrophilic/hydrophobic patterned nanochannels
Hiroto Kawagishi, Shuichi Kawamata, Yan Xu Proceedings of Micro Total Analysis Systems, 2020, 190-191.
Fabrication of sub-40-nanometer nano-in-nano structures in nanochannels
Hiroki Kamai, Yan Xu Proceedings of Micro Total Analysis Systems, 2020, 366-367.
Fabrication and evaluation of flexible nanovalves in 2D-nanochannels
Hiroto Kawagishi, Shun-ichi Funano, Yo Tanaka, Shuichi Kawamata and Yan
Xu Proceedings of Micro Total Analysis Systems, 2019, 1182-1183.
Nanofluidics: a New Arena for Materials Science (invited) Yan Xu Advanced Materials, 2018, 30, 1702419. (doi:10.1002/adma.201702419) [PDF] (Featured on the inside back cover of the journal ) (2nd place among Top ten hot papers/Top ten most accessed papers of Advanced
Materials, November, 2017)
Antifouling surface modification of nanochannels using a silanized phospholipid monomer
Qian Wu, Yan Xu Proceedings of Micro Total Analysis Systems, 2016, 1152-1153.
１兆分の1 mLの水を自在に制御できる技術 (A Technique Enabling the Active Regulation of Femtoliter-Scale Liquids) 許 岩 (Yan Xu) 自動車技術 （「超の世界」） (Journal of Society of Automotive Engineers of Japan), 2016, 70 (9), 122-123.
リン脂質ポリマーハイドロゲルを用いたOn-Chip細胞保存（On-Chip Cell Preservation by Using a Phospholipid
Polymer Hydrogel) 許 岩 (Yan Xu) 色材協会誌（Journal of the Japan Society of colour Material）, 2016, 89(5), 154-158.
Design, synthesis and characterization of a thiolated temperature-responsive
polymer for smart nanofluidic control
Misato Shinomiya, Atsushi Harada, Yan Xu Proceedings of Micro Total Analysis Systems, 2014, 1841-1843.[PDF]
Arbitrary nanopatterning inside nanochannels by integration of top-down
and bottom-up approaches for single molecule analysis
Nobuhiro Matsumoto, Yan Xu Proceedings of Micro Total Analysis Systems, 2013, 119-121.[PDF]
A room-temperature bonding of glass nanofluidic chips utilizing a surface
activation with a fluorine-containing plasma treatment
Yan Xu, Chenxi Wang, Kihoon Jang, Lixiao Li, Nobuhiro Matsumoto, Yiyang Dong, Kazuma Mawatari, Tadatomo Suga, Takehiko Kitamorii Proceedings of Micro Total Analysis Systems, 2012, 1225-1227.[PDF]
Temperature-flexible cell microcontainers fabricated with a phosphorylcholine polymer hydrogel on chip
Yan Xu, Kazuma Mawatari, Tomohiro Konno, Kazuhiko Ishihara, Takehiko Kitamori Proceedings of Micro Total Analysis Systems, 2012, 1048-1050.[PDF]
Development of fluorine induced plasma activating room-temperature bonding
strategy for high-pressure micro-nano fluidic devices
Kihoon Jang, Chenxi Wang, Yan Xu, Takehiko Kitamorii Proceedings of Micro Total Analysis Systems, 2012, 1237-1239.[PDF]
Nano Laplace valve for femtolitter liquid generation and handling realized
by nanopillar-in-nanochannel fabrication and surface modification
Kazuma Mawatari, Shogo Kubota, Yan Xu, Takehiko Kitamori Proceedings of Micro Total Analysis Systems, 2012, 1447-1449.[PDF]
Cell-based toxin screening integrated with a cell-sustainable hydrogel
on chip for onsite and portable applications
Yan Xu, Kihoon Jang, Kazuma Mawatari, Tomohiro Konno, Kazuhiko Ishihara,
Takehiko Kitamori Proceedings of Micro Total Analysis Systems, 2010, 1, 1499-1501.[PDF]
An on-chip living cell bank
Yan Xu, Kae Sato, Tomohiro Konno, Kazuhiko Ishihara, Takehiko Kitamori Proceedings of Micro Total Analysis Systems, 2009, 2, 1952-1954.
2008
Long-term storage of living cells on chip for cell-based assays
Yan Xu, Kae Sato, Tomohiro Konno, Kazuhiko Ishihara, Takehiko Kitamori
Proceedings of Micro Total Analysis Systems, 2008, 2, 1852-1854.[PDF]
Microfluidic flow control on charged phospholipid polymer interface
Yan Xu, Madoka Takai, Tomohiro Konno, Kazuhiko Ishihara Lab on a Chip, 2007, 7,199-206. (DOI: 10.1039/B616851P) [PDF][Correction] (Featured on the cover of the journal, on Royal Society of Chemistry (RSC) web page,and on University
of Tokyo-CNBI Topics, and was one of the ten most accessed articles of
Lab on a chip in February, 2007)
Charged phospholipid polymer surfaces with high cell adhesion resistance
for cell chip
Yan Xu, Tomohiro Konno, Madoka Takai, Kazuhiko Ishihara Proceedings of Micro Total Analysis Systems, 2007, 1, 424-426.
Protein antiadsorption modification by negatively charged phospholipid
polymer for microsystem needing electroosmotic flow
Yan Xu, Madoka Takai, Tomohiro Konno, Kazuhiko Ishihara Proceedings of Micro Total Analysis Systems, 2006, 1, 215-217.
Ma Xiaojun, Xu Yan, Wang Wei. Calcium alginate gel microsphere soft tissue
reinforced material and its preparation method and application. China Patent,
Patent Number(s): CN1628862-A, CN1306968-C.
Ma Xiaojun, Xu Yan, Wang Wei.. Chitosan-calcium alginate gel microsphere
soft tissue reinforced material and its preparation method and application.
China Patent, Patent Number(s): CN1628861-A, CN1318100-C
■ Conference Oral Presentations
Xu Yan, Takai Madoka, Kitamori Takehiko. Bioinspired micro/nano interfaces
and devices based on 2-methacryloyloxyethyl phosphorylcholine polymers,
"15th International Conference on Thin Films, 2011 (ICTF-15)".
Kyoto, Japan, Nov., 2011.
Xu Yan. Creation of micro/nano interfaces and integrated devices at the
molecular and cellular levels, “Aptamer and Microfluidic Seminar for Food
Ssafety and Related Science”. Beijing, China, Oct., 2011. (Invited)
Umeda Jun, Wang Chenxi, Xu Yan, Mawatari Kazuma, Kitamori Takehiko, Suga
Tadatomo. Low temperature bonding of glasses by means of surface activation
using water, "25th Spring Conference of Japan Institute of Electronics
Packaging". Yokohama, Japan, Mar., 2011.
Jang Kihoon, Kogo Atsushi, Mawatari, K.; Xu Yan, Kitamori Takehiko. Heat
pipe with extended nanopillar inside the micro-nano combined chip. "The
2010 International Chemical Congress of Pacific Basin Societies (Pacifichem
2010)". Hawaii, USA, Dec., 2010.
Xu Yan, Kitamori Takehiko. Partial Surface Modification Methods for Extended-Nano
Space Using Nanostructure Fabrication. "2nd Iwan Wark Research Institute
Joint Seminar". Adelaide, Australia, Dec., 2009.
Xu Yan, Sato Kae, Konno Tomohiro, Ishihara Kazuhiko, Kitamori Takehiko.
Cell-based assays on a chip with a cell bank. "23rd International
Symposium on Microscale Bioseparations(MSB)". Boston, USA, Feb. 2009.
Xu Yan, Takai Madoka, Ishihara Kazuhiko. Nonbiofouling anionic phospholipid
polymer modification for electrokinetic microfluidic device. "The
Society For Biomaterials (SFB) 2007 Annual Meeting and Exposition".
Chicago, USA. Apr. 2007.
Xu Yan, Takai Madoka, Ishihara Kazuhiko. Control of microflow on polymer
biointerface in electrokinetic microfluidic device. "The Japan Society
of Applied Physics (JSAP) 2007 Spring Annual Meeting". Sagamihara,
Japan. Mar. 2007.
Takai Madoka, Sibarani James, Xu Yan, Ishihara Kazuhiko. Protein adsorption
resistance on biochip surface by phospholipid polymers. "20th European
Conference on Biomaterials (ESB2006)". Nantes, France. Sep. 2006.
Xu Yan, Takai Madoka, Konno Tomohiro, Ishihara Kazuhiko. Antiprotein adsorption
interface on biochip prepared by a negatively charged phospholipid polymer.
"7th Asian Symposium on Biomedical Materials (ASBM-7)". Jeju,
Korea. Aug., 2006.
Xu Yan, Takai Madoka, Ishihara Kazuhiko. Microfluidic devices with "smart"
surface for cell separation. "The Japanese Society for Biomaterials
27th Annual Meeting". Kyoto, Japan. Oct. 2005.
■ Conference Poster Presentations
2012
Xu Y., Wang C, Jang K, Li L, Matsumoto N., Dong Y., Mawatari K., Suga T.,
Kitamori T. A room-temperature bonding of glass nanofluidic chips utilizing
a surface activation with a fluorine-containing plasma treatment. "16th
International Conference on Miniaturized Systems for Chemistry and Life
Sciences (microTAS2012)". Okinawa, Japan, Oct. 2012.
Jang K., Wang C., Xu Y., Kitamori T. Development of fluorine induced plasma
activating room-temperature bonding stratage for high-pressure micro-nano
fluidic devices. "16th International Conference on Miniaturized Systems
for Chemistry and Life Sciences (microTAS2012)". Okinawa, Japan, Oct.
2012.
Mawatari K., Kubota S., Xu Y., Kitamori T. Nano Laplace valve for femtolitter
liquid generation and handling realized by nanopillar-in-nanochannel fabrication
and surface modification. "16th International Conference on Miniaturized
Systems for Chemistry and Life Sciences (microTAS2012)". Okinawa,
Japan, Oct. 2012.
Xu Yan, Wang Chenxi, Li Lixiao, Matsumoto Nobuhiro, Jang Kihoon, Dong Yiyang, Mawatari Kazuma, Suga Tadatomo, Kitamori Takehiko. A novel bonding method of glass nanofluidic chips at room temperature. “4th International Symposium on Microchemistry and Microsystems (ISMM 2012)”. Hsinchu, Jun., 2012.
Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. Attoliter scale liquid handling using Laplace valve in Extended Nanospace. “4th International Symposium on Microchemistry and Microsystems (ISMM 2012)”. Hsinchu, Jun., 2012.
Wang Chenxi, Xu Yan, Jang Kihoon, Shirai Kentaro, Mawatari Kazuma, Suga Tadatomo, Kitamori Takehiko. Precise Alignment Technique for Creating Micro/Nanofluidic Devices. “4th International Symposium on Microchemistry and Microsystems (ISMM 2012)”. Hsinchu, Jun., 2012.
Xu Yan, Wang Chenxi, Li Lixiao, Matsumoto Nobuhiro, Jang Kihoon, Dong Yiyang,
Mawatari Kazuma, Suga Tadatomo, Kitamori Takehiko. A super high pressure
resistant bonding of glass nanochannels at room temperature using an O2/CF4 gas mixture plasma treatment for nanochromatography sample handling. "27th International Symposium on MicroScale BioSeparations and Analyses (MSB2012)". Geneva, Switzerland, Feb., 2012.
Jang Kihoon, Xu Yan, Mawatari Kazuma, Kitamori Takehiko. Simplified room-temperature
bonding of fused silica glass micro-nanofluidic device by using fluorine
induced plasma treatment with Teflon pieces. "27th International Symposium
on MicroScale BioSeparations and Analyses (MSB2012)". Geneva, Switzerland,
Feb., 2012.
Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. Laplace pressure
valve utilizing nano-in-nano structure toward attoliter scale liquid handling.
"15th International Conference on Miniaturized Systems for Chemistry
and Life Sciences (microTAS2011)". Seattle, USA, Oct. 2011.
Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. Development of
aL scale liquid handling method in extended nanospace. “JAIMA Discussion
on Analytical Science and Technology 2011, International Session”. Chiba,
Japan, Sept. 2011.
Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. Development of
Laplace Pressure Valve for Chromatography System in Extended-nano Space.
"The 36th International Symposium on High Performance Liquid Phase
Separations and Related Techniques (HPLC 2011)". Budapest, Hungary,
Jun, 2011.
Xu Yan, Wang Chenxi, Li Lixiao, Dong Yiyang, Jang Kihoon, Suga Tadatomo,
Mawatari Kazuma, Kitamori Takehiko. Low-temperature glass chip bonding.
"The International Symposium on Microchemistry and Microsystems 2011
(ISMM 2011)". Seoul, Korea, Jun., 2011.
Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. A Laplace valve
in extended-nano channel for attoliter-level liquid injection. "The
International Symposium on Microchemistry and Microsystems 2011 (ISMM 2011)".
Seoul, Korea, Jun., 2011.
Jang Kihoon, Ngo Thi Hong Trang, Tanaka, Yo, Xu Yan, Kitamori Takehiko.
Development of single cell analysis device using single cell-array and
culture techniques in a microfluidic system. "The International Symposium
on Microchemistry and Microsystems 2011 (ISMM 2011)". Seoul, Korea,
Jun., 2011.
Xu Yan, Wang Chenxi, Dong Yiyang, Jang Kihoon, Suga Tadatomo, Mawatari
Kazuma, Kitamori Takehiko. Bonding of glass nanofluidic chips at low temperature.
"IUPAC International Congress on Analytical Sciences 2011 (ICAS 2011)".
Kyoto, Japan, May, 2011.
Dong Yiyang, Xu Yan, Liu Zaixin, Fu Yuanfang, Ohashi Toshinori, Mawatari
Kazuma, Kitamori Takehiko. Screening swine type O foot-and-mouth disease
virus with micro-beads based microfluidic thermal lens microscopy. "IUPAC
International Congress on Analytical Sciences 2011 (ICAS 2011)". Kyoto,
Japan, May, 2011.
Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. A Laplace pressure
valve to control nanofluidics for chromatography systems in extended-nano
space. "IUPAC International Congress on Analytical Sciences 2011 (ICAS
2011)". Kyoto, Japan, May, 2011.
Jang Kihoon, Iseki Keizo, Kogo Atsushi, Xu Yan, Mawatari Kazuma, Sugii
Yasuhiko, Kitamori Takehiko. A flat heat pipe system contained capillary
condensation and vapor-liquid coexisting process based on extended nanopillar.
"IUPAC International Congress on Analytical Sciences 2011 (ICAS 2011)".
Kyoto, Japan, May, 2011.
Wang Chenxi, Xu Yan, Umeda Jun,Dong Yiyang, Mawatari Kazuma, Kitamori Takehiko,
Suga Tadatomo. A novel biocompatible direct bonding for glass microdevices.
"International Conference on Electronics Packaging 2011 (ICEP 2011)".
Nara, Japan, Apr. 2011.
2010
Xu Yan, Jang Kihoon, Mawatari Kazuma, Konno Tomohiro, Ishihara Kazuhiko,
Kitamori Takehiko. A microfluidic hydrogel for more flexible cell-based
applications. "The 2010 International Chemical Congress of Pacific
Basin Societies (Pacifichem 2010)". Hawaii, USA, Dec., 2010.
Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. Development of
Laplace valves capable of attoliter level injection for chromatography
systems in extended-nano space. "10th Asian-Pacific International
Symposium on Microscale Separations and Analysis (APCE 2010)". Hongkong,
China, Dec., 2010.
Xu Yan, Jang Kihoon, Mawatari Kazuma, Konno Tomohiro, Ishihara Kazuhiko,
Kitamori Takehiko. Cell-based toxin screening integrated with a cell-sustainable
hydrogel on chip for onsite and portable applications. "14th International
Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2010)".
Groningen, The Netherlands, Oct., 2010.
Jang Kihoon, Xu Yan, Tanaka Yo, Kitamori Takehiko. Multi-patterning of
biological samples on glass substrate and inside the fused microchannel
by using photochemical reaction. "17th International Symposium on
Capillary Electroseparation Techniques (ITP 2010 USA)". Baltimore,
USA, Aug, 2010.
Xu Yan, Ishihara Kazuhiko, Kitamori Takehiko. A microfluidic cell-based
biosensor with integration of a phospholipid polymer hydrogel for onsite
and portable applications. "Gordon Research Conferences-Bioanalytical
Sensors". New London, USA, Jun., 2010.
Jang Kihoon, Xu Yan, Tanaka Yo, Mawatari Kazuma, Kitamori Takehiko. Direct
approach to modify individual cells in microfluidic device for single cell
analysis. "21th Symposium on Chemistry and Micro-Nano Systems".
Tokyo, Japan. Jun., 2010.
Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. Development of
Laplace valves in extended-nano space using nano fabrication. "21th
Symposium on Chemistry and Micro-Nano Systems". Tokyo, Japan. Jun.,
2010.
Xu Yan, Jang Kihoon, Konno Tomohiro, Ishihara Kazuhiko, Mawatari Kazuma,
Kitamori Takehiko. Comparative investigation on long-term cellular functions
of cells in a microfluidic hydrogel capable of cell preservation. "International
Symposium on Microchemistry and Microsystems (ISMM) 2010". Hongkong,
China, May, 2010.
Kubota Shogo, Mawatari Kazuma, Xu Yan, Kitamori Takehiko. Development of
Laplace valve in extended-nano space using well-defined patterning by nanostructure.
"International Symposium on Microchemistry and Microsystems (ISMM)
2010". Hongkong, China, May, 2010.
Jang Kihoon, Xu Yan, Tanaka Yo, Kitamori Takehiko. A method for single cell patterning by using photochemical reaction in
fused micrcoahnnel. "International Symposium on Microchemistry and
Microsystems (ISMM) 2010". Hongkong, China, May, 2010.
Xu Yan, Jang Kihoon, Konno Tomohiro, Ishihara Kazuhiko, Mawatari Kazuma,
Kitamori Takehiko. A microfluidic hydrogel for long-term cell preservation
under cell-based assay conditions. "25th International Symposium on
Microscale Bioseparations (MSB)". Prague, Czech, Mar., 2010.
Jang Kihoon, Xu Yan, Tanaka Yo, Kitamori Takehiko. Single cell patterning
in semi-closed microchannel using photoactivation. "25th International
Symposium on Microscale Bioseparations (MSB)". Prague, Czech, Mar.,
2010.
2009
Xu Yan, Sato Kae, Konno Tomohiro, Ishihara Kazuhiko, Kitamori Takehiko.
An on-chip living cell bank. "13th International Conference on Miniaturized
Systems for Chemistry and Life Sciences (microTAS2009)". Jeju, Korea.
Nov., 2009.
Xu Yan, Mawatari Kazuma, Konno Tomohiro, Ishihara Kazuhiko, Kitamori Takehiko.
Cell bank on chip working at room temperature. "24th International
Symposium on Microscale Bioseparations (MSB)". Dalian, China, Oct.,
2009.
Xu Yan, Sato Kae, Mawatari Kazuma, Konno Tomohiro, Ishihara Kazuhiko, Kitamori
Takehiko. Long-term cell preservation in chip at room temperature. "19th
Symposium on Chemistry and Micro-Nano Systems". Hiroshima, Japan.
May, 2009.
2008
Xu Yan, Sato Kae, Konno Tomohiro, Ishihara Kazuhiko, Kitamori Takehiko.
Cell-based assays supported by a cell bank on chip. "International
Symposium on Microchemistry and Microsystems (ISMM) 2008". Kyoto,
Japan. Dec. 2008.
Xu Yan, Konno Tomohiro, Sato Kae, Ishihara Kazuhiko, Kitamori Takehiko.
Long-term storage of living cells on chip for cell-based assays. "12th
International Conference on Miniaturized Systems for Chemistry and Life
Sciences (microTAS2008)". San Diego, USA. Oct., 2008.
Xu Yan, Takai Madoka, Konno Tomohiro, Ishihara Kazuhiko. Suppressing bioadsorption
on electrokinetic microdevice by a charged phospholipid polymer biointerface.
"8th World Biomaterials Congress (WBC2008)". Amsterdam, The Netherlands.
May, 2008.
Xu Yan, Sato Kae, Konno Tomohiro, Ishihara Kazuhiko, Kitamori Takehiko.
Long-term encapsulation of living cells on chip by using a phospholipid
polymer hydrogel. "17th Symposium on Chemistry and Micro-Nano Systems".
Fukuoka, Japan. May, 2008.
2007
Xu Yan, Konno Tomohiro, Takai Madoka, Ishihara Kazuhiko. Charged phospholipid
polymer surfaces with high cell adhesion resistance for cell chip. "11th
International Conference on Miniaturized Systems for Chemistry and Life
Sciences (microTAS2007)". Paris, France. Oct., 2007.
Xu Yan, Takai Madoka, Ishihara Kazuhiko. Phospholipid polymer surface for
control of both protein adsorption and liquid flow in microfluidic device.
"The Society of Polymer Science Japan (SPSJ) 56th Annual Meeting".
Kyoto, Japan. May, 2007.
2006
Xu Yan, Takai Madoka, Konno Tomohiro, Ishihara Kazuhiko. Protein antiadsorption
modification by negatively charged phospholipid polymer for microsystem
needing electroosmotic flow. "10th International Conference on Miniaturized
Systems for Chemistry and Life Sciences (microTAS2006)". Tokyo, Japan.
Nov., 2006.
Xu Yan, Takai Madoka, Konno Tomohiro, Ishihara Kazuhiko. Biomembrane mimetic
anti-bioadsorption interface constructed for microfluidic devices. "The
Society of Polymer Science Japan (SPSJ) 55th Annual Meeting". Nagoya,
Japan. May, 2006.
2005
Xu Yan, Takai Madoka, Ishihara Kazuhiko. Constructing biomembrane-mimic
interface in microfluidic chip for cell separation. "16th Materials
Research Society (MRS)-Japan Academic Symposium". Tokyo, Japan. Dec.,
2005.
Xu Yan, Konno Tomohiro, Ishihara Kazuhiko, Takai Madoka. Microfluidic interface
constructed by biomimic membrane for cell separation chip. "Asian
Conference on Recent Trends in Colloid and Surface Science (ACCASS)".
Nagoya, Japan. Dec., 2005.
